CPPsite: a curated database of cell penetrating peptides
نویسندگان
چکیده
منابع مشابه
CPPsite: a curated database of cell penetrating peptides
Delivering drug molecules into the cell is one of the major challenges in the process of drug development. In past, cell penetrating peptides have been successfully used for delivering a wide variety of therapeutic molecules into various types of cells for the treatment of multiple diseases. These peptides have unique ability to gain access to the interior of almost any type of cell. Due to the...
متن کاملCPPsite 2.0: a repository of experimentally validated cell-penetrating peptides
CPPsite 2.0 (http://crdd.osdd.net/raghava/cppsite/) is an updated version of manually curated database (CPPsite) of cell-penetrating peptides (CPPs). The current version holds around 1850 peptide entries, which is nearly two times than the entries in the previous version. The updated data were curated from research papers and patents published in last three years. It was observed that most of t...
متن کاملCell Penetrating Peptides
During the last ten years it has been observed that a number of peptides and proteins are able to penetrate the cell membrane and enter the cell. Furthermore, it has been shown that even many cargo molecules that are covalently attached to these peptides will be translocated into the cell. Peptides that show the ability to translocate through the cell membrane are usually short peptides of less...
متن کاملIdentification and characterization of a new family of cell-penetrating peptides: cyclic cell-penetrating peptides.
Cell-penetrating peptides can translocate across the plasma membrane of living cells and thus are potentially useful agents in drug delivery applications. Disulfide-rich cyclic peptides also have promise in drug design because of their exceptional stability, but to date only one cyclic peptide has been reported to penetrate cells, the Momordica cochinchinensis trypsin inhibitor II (MCoTI-II). M...
متن کاملcell-penetrating peptides (cpps): a tool in modern biotechnology
the major limitation in the application of bioactive molecule is their low permeation across plasma membrane. in 1988 it was discovered, that a natural polycationic protein, the trans-acting activator of transcription (tat) of the human immunodeficiency virus (hiv-1), passed very efficiently through cell membrane of cultured mammalian cells. tat became known as the first cell penetrating peptid...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Database
سال: 2012
ISSN: 1758-0463
DOI: 10.1093/database/bas015